Chlorothalonil

Active IngredientChlorothalonil
ClassificationFungicide / Agrochemical
Formulation75%WP, 75%WDG
BiochemistryConjugation with, and depletion of, thiols (particularly glutathione) from germinating fungal cells, leading to disruption of glycolysis and energy production, fungi stasis and fungicidal action.
Mode of ActionNon-systemic foliar fungicide with protective action.  
UsageControl of many fungal diseases in a wide range of crops, including pome fruit, stone fruit, citrus fruit, bush and cane fruit, cranberries, strawberries, pawpaws, bananas, mangoes, coconut palms, oil palms, rubber, pepper, vines, hops, vegetables, cucurbits, tobacco, coffee, tea, rice, soya beans, peanuts, potatoes, sugar beet, cotton, maize, ornamentals, mushrooms, and turf. Application rates for food crops are 1-2.5 kg/ha.
PhytotoxicityRussetting is possible with flowering ornamentals, apples, and grapes. Some varieties of flowering ornamentals may be injured. Pittosporum foliage is sensitive. Phytotoxicity may be increased with oils or oil-containing substances.
Mammalian ToxicologyOral: Acute oral LD50 for rats >5000 mg/kg.  
Skin and eye: Acute percutaneous LD50 for albino rabbits >5000 mg/kg. Severe eye irritant; mild skin irritant (rabbits). Evidence in humans of contact dermatitis with repeated exposure.
Inhalation: LC50 (1 h) for rats 0.52 mg/l air; (4 h) for rats 0.10 mg/l air.