Fludioxonil

Active IngredientFludioxonil
ClassificationFungicide / Agrochemical
Formulation98%Tech 25g/L FS Fludixonil 25%+Cyprodinil37.5%WDG
Mode of ActionThe inhibition of transport-associated phosphorylation of glucose as well as preventing glycerol synthesis
UsageBeing broad spectrum fludioxonil is effective against most major seed diseases, including Seedling blight, Stem-Base Browning, Snow Mould and Common Bunt. In post-harvest situations it is effective against Grey mould, Black Spot, storage rot and Powdery Mildew. In combination with thiamethoxam and metalaxyl-M, fludioxonil also acts as an insecticide seed treatment, effectively preventing peach-potato aphid, flea beetle and cabbage stem flea beetle. Fludioxonil is approved as a seed treatment for oats, barley, wheat, triticale and rye. It can be applied directly to amenity grassland, managed amenity turf, fodder rape, mustard and oil seed rape. It can be used as a post harvest treatment on apples, bilberries, blackberries, blackcurrants, blueberries, broad beans, combining peas, crab apples, cranberries, dwarf french beans, edible podded peas, forest nursery, gooseberries, ornamental plant production, pears, quinces, raspberries, redcurrants, runner beans, strawberries, vining peas and white currants.
Mammalian ToxicologyFludioxonil is not acutely toxic via oral, dermal and inhalation route (LD50>5000 mg/kg/bw, LD50 >2000 mg/kg bw and LC50 >2.6 mg/L, respectively). It is not a skin and eye irritant. Fludioxonil is not a skin sensitiser. Target organs after repeated oral administration are liver in rats, mice and dogs (increased weight, hepatocyte hypertrophy, bile duct proliferation) and kidneys in rats and mice (increased weight, nephropathy). The relevant oral NOAEL is 58.5 mg/kg bw/day from the 90-day study in dog. The NOAEL from the repeated dose dermal study in rats is 200 mg/kg bw/day. Fludioxonil does not show any genotoxic, teratogenic and carcinogenic potential. The relevant NOAEL for chronic toxicity is 37 mg/kg bw/day. The ADI of fludioxonil is 0.37 mg/kg bw/day from the relevant long term/carcinogenicity NOAEL applying a safety factor of 100. The proposed AOEL is 0.59 mg/kg bw/day from the NOAEL of the 90-day study in dogs with a safety factor of 100. The allocation of an ARfD was not considered necessary.